About 1 result found for searched term "(R)-CR8 trihydrochloride" (0.158 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21148 | (R)-CR8 trihydrochloride | CDK |
| CR8, (R)-Isomer trihydrochloride | ||
| (R)-CR8 trihydrochloride, one of the isomers of CR8, is a potent CDK1/2/5/7/9 inhibitor with anti-proliferative and pro-apoptotic effects on CML cell lines. (R)-CR8 trihydrochloride inhibited CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM ), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). | ||
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